Fig. 5
From: Drug mechanism enrichment analysis improves prioritization of therapeutics for repurposing
DMEA identifies selectively toxic MOAs based on cell viability connectivity scores. Rank-ordered drug lists were generated by querying the PRISM database with input cell line sets characterized by A the activating EGFR mutation p.E746_A750del, B high expression of PDGFRA, and C sensitivity to the HMGCR inhibitor lovastatin. Volcano plots summarizing the NES and − log10(p value) for all tested drug MOAs and mountain plots of the expected MOAs are shown. Red text indicates MOAs with p value < 0.05 and FDR < 0.25. For each mountain plot, the inhibitors with the most positive connectivity scores are highlighted