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Page 184 of 191

  1. Content type: Research article

    Gene expression analysis based on comparison of electrophoretic patterns is strongly dependent on the accuracy of DNA fragment sizing. The current normalization strategy based on molecular weight markers has l...

    Authors: Koji Kadota, Ryutaro Fukumura, Joseph J Rodrigue, Ryoko Araki and Masumi Abe

    Citation: BMC Bioinformatics 2005 6:43

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  2. Content type: Software

    Phages, viruses that infect prokaryotes, are the most abundant microbes in the world. A major limitation to studying these viruses is the difficulty of cultivating the appropriate prokaryotic hosts. One way ar...

    Authors: Florent Angly, Beltran Rodriguez-Brito, David Bangor, Pat McNairnie, Mya Breitbart, Peter Salamon, Ben Felts, James Nulton, Joseph Mahaffy and Forest Rohwer

    Citation: BMC Bioinformatics 2005 6:41

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  3. Content type: Methodology article

    Normalization is the process of removing non-biological sources of variation between array experiments. Recent investigations of data in gene expression databases for varying organisms and tissues have shown t...

    Authors: Tim Lu, Christine M Costello, Peter JP Croucher, Robert Häsler, Günther Deuschl and Stefan Schreiber

    Citation: BMC Bioinformatics 2005 6:37

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  4. Content type: Methodology article

    One important application of microarray experiments is to identify differentially expressed genes. Often, small and negative expression levels were clipped-off to be equal to an arbitrarily chosen cutoff value...

    Authors: Markus Neuhäuser, Tanja Boes and Karl-Heinz Jöckel

    Citation: BMC Bioinformatics 2005 6:35

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  5. Content type: Database

    We present a biological data warehouse called Atlas that locally stores and integrates biological sequences, molecular interactions, homology information, functional annotations of genes, and biological ontolo...

    Authors: Sohrab P Shah, Yong Huang, Tao Xu, Macaire MS Yuen, John Ling and BF Francis Ouellette

    Citation: BMC Bioinformatics 2005 6:34

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  6. Content type: Research article

    Detection of DNA-binding sites in proteins is of enormous interest for technologies targeting gene regulation and manipulation. We have previously shown that a residue and its sequence neighbor information can...

    Authors: Shandar Ahmad and Akinori Sarai

    Citation: BMC Bioinformatics 2005 6:33

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  7. Content type: Methodology article

    Wise et al. introduced a rank-based statistical technique for meta-analysis of genome scans, the Genome Scan Meta-Analysis (GSMA) method. Levinson et al. recently described two generalizations of the GSMA stat...

    Authors: James A Koziol and Anne C Feng

    Citation: BMC Bioinformatics 2005 6:32

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  8. Content type: Research article

    Cellular processes require the interaction of many proteins across several cellular compartments. Determining the collective network of such interactions is an important aspect of understanding the role and re...

    Authors: Harold J Drabkin, Christopher Hollenbeck, David P Hill and Judith A Blake

    Citation: BMC Bioinformatics 2005 6:29

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  9. Content type: Research article

    Normalization is a critical step in analysis of gene expression profiles. For dual-labeled arrays, global normalization assumes that the majority of the genes on the array are non-differentially expressed betw...

    Authors: Yingdong Zhao, Ming-Chung Li and Richard Simon

    Citation: BMC Bioinformatics 2005 6:28

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  10. Content type: Research article

    Microarray-CGH experiments are used to detect and map chromosomal imbalances, by hybridizing targets of genomic DNA from a test and a reference sample to sequences immobilized on a slide. These probes are geno...

    Authors: Franck Picard, Stephane Robin, Marc Lavielle, Christian Vaisse and Jean-Jacques Daudin

    Citation: BMC Bioinformatics 2005 6:27

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  11. Content type: Research article

    A critical step in processing oligonucleotide microarray data is combining the information in multiple probes to produce a single number that best captures the expression level of a RNA transcript. Several sys...

    Authors: Kerby Shedden, Wei Chen, Rork Kuick, Debashis Ghosh, James Macdonald, Kathleen R Cho, Thomas J Giordano, Stephen B Gruber, Eric R Fearon, Jeremy MG Taylor and Samir Hanash

    Citation: BMC Bioinformatics 2005 6:26

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  12. Content type: Research article

    Alternative splicing (AS) is now considered as a major actor in transcriptome/proteome diversity and it cannot be neglected in the annotation process of a new genome. Despite considerable progresses in term of...

    Authors: Sylvain Foissac and Thomas Schiex

    Citation: BMC Bioinformatics 2005 6:25

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  13. Content type: Research article

    Current protein clustering methods rely on either sequence or functional similarities between proteins, thereby limiting inferences to one of these areas.

    Authors: Victor Kunin and Christos A Ouzounis

    Citation: BMC Bioinformatics 2005 6:24

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  14. Content type: Research article

    Post-translational modification by Small Ubiquitin-like Modifiers (SUMO) has been implicated in protein targeting, in the maintenance of genomic integrity and in transcriptional control. But the specific molec...

    Authors: Maria Novatchkova, Andreas Bachmair, Birgit Eisenhaber and Frank Eisenhaber

    Citation: BMC Bioinformatics 2005 6:22

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  15. Content type: Software

    The large amount of data that are currently produced in the biological sciences can no longer be explored and visualized efficiently with traditional, specialized software. Instead, new capabilities are needed...

    Authors: John L Moreland, Apostol Gramada, Oleksandr V Buzko, Qing Zhang and Philip E Bourne

    Citation: BMC Bioinformatics 2005 6:21

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  16. Content type: Methodology article

    The process of oxidative folding combines the formation of native disulfide bond with conformational folding resulting in the native three-dimensional fold. Oxidative folding pathways can be described in terms...

    Authors: Vilmos Ágoston, Masa Cemazar, László Kaján and Sándor Pongor

    Citation: BMC Bioinformatics 2005 6:19

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  17. Content type: Software

    Detection of Loss of Heterozygosity (LOH) is one of the most common molecular applications in the study of human diseases, in particular cancer. The technique is commonly used to examine whether a known tumour...

    Authors: Rifat A Hamoudi, Amina El-Hamidi and Ming-Qing Du

    Citation: BMC Bioinformatics 2005 6:18

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  18. Content type: Research article

    Enzyme-linked immunosorbent assay (ELISA) is a standard immunoassay to estimate a protein's concentration in a sample. Deploying ELISA in a microarray format permits simultaneous estimation of the concentratio...

    Authors: Don Simone Daly, Amanda M White, Susan M Varnum, Kevin K Anderson and Richard C Zangar

    Citation: BMC Bioinformatics 2005 6:17

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  19. Content type: Methodology article

    Searching a biological sequence database with a query sequence looking for homologues has become a routine operation in computational biology. In spite of the high degree of sophistication of currently availab...

    Authors: Antje Krause, Jens Stoye and Martin Vingron

    Citation: BMC Bioinformatics 2005 6:15

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  20. Content type: Methodology article

    Recent analysis of the yeast gene network shows that most genes have few inputs, indicating that enumerative gene reconstruction methods are both useful and computationally feasible. A simple enumerative recon...

    Authors: Thomas MacCarthy, Andrew Pomiankowski and Robert Seymour

    Citation: BMC Bioinformatics 2005 6:11

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  21. Content type: Research article

    Prediction of the transmembrane strands and topology of β-barrel outer membrane proteins is of interest in current bioinformatics research. Several methods have been applied so far for this task, utilizing dif...

    Authors: Pantelis G Bagos, Theodore D Liakopoulos and Stavros J Hamodrakas

    Citation: BMC Bioinformatics 2005 6:7

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  22. Content type: Methodology article

    Complex biological database systems have become key computational tools used daily by scientists and researchers. Many of these systems must be capable of executing on multiple different hardware and software ...

    Authors: Marko Srdanovic, Ulf Schenk, Michael Schwieger and Fabien Campagne

    Citation: BMC Bioinformatics 2005 6:5

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  23. Content type: Methodology article

    Structure-dependent substitution matrices increase the accuracy of sequence alignments when the 3D structure of one sequence is known, and are successful e.g. in fold recognition. We propose a new automated me...

    Authors: Jean-Christophe Gelly, Laurent Chiche and Jérôme Gracy

    Citation: BMC Bioinformatics 2005 6:4

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  24. Content type: Research article

    Two or more factor mixed factorial experiments are becoming increasingly common in microarray data analysis. In this case study, the two factors are presence (Patients with Alzheimer's disease) or absence (Con...

    Authors: Hao Li, Constance L Wood, Thomas V Getchell, Marilyn L Getchell and Arnold J Stromberg

    Citation: BMC Bioinformatics 2004 5:209

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  25. Content type: Database

    G protein-coupled receptors (GPCRs) transduce signals from extracellular space into the cell, through their interaction with G proteins, which act as switches forming hetero-trimers composed of different subun...

    Authors: Antigoni L Elefsinioti, Pantelis G Bagos, Ioannis C Spyropoulos and Stavros J Hamodrakas

    Citation: BMC Bioinformatics 2004 5:208

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  26. Content type: Research article

    Many real networks can be understood as two complementary networks with two kind of nodes. This is the case of metabolic networks where the first network has chemical compounds as nodes and the second one has ...

    Authors: Jose C Nacher, Nobuhisa Ueda, Takuji Yamada, Minoru Kanehisa and Tatsuya Akutsu

    Citation: BMC Bioinformatics 2004 5:207

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  27. Content type: Methodology article

    Protein-protein interactions play a critical role in protein function. Completion of many genomes is being followed rapidly by major efforts to identify interacting protein pairs experimentally in order to dec...

    Authors: Taner Z Sen, Andrzej Kloczkowski, Robert L Jernigan, Changhui Yan, Vasant Honavar, Kai-Ming Ho, Cai-Zhuang Wang, Yungok Ihm, Haibo Cao, Xun Gu and Drena Dobbs

    Citation: BMC Bioinformatics 2004 5:205

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  28. Content type: Methodology article

    High-density oligonucleotide microarray technology enables the discovery of genes that are transcriptionally modulated in different biological samples due to physiology, disease or intervention. Methods for th...

    Authors: Norman Pavelka, Mattia Pelizzola, Caterina Vizzardelli, Monica Capozzoli, Andrea Splendiani, Francesca Granucci and Paola Ricciardi-Castagnoli

    Citation: BMC Bioinformatics 2004 5:203

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2018 Journal Metrics

  • Citation Impact
    2.511 - 2-year Impact Factor
    2.970 - 5-year Impact Factor
    0.855 - Source Normalized Impact per Paper (SNIP)
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