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  1. Content type: Research article

    Identification and characterization of novel Plasmodium gene families is necessary for developing new anti-malarial therapeutics. The products of the Plasmodium falciparum gene, MB2, were shown previously to have...

    Authors: Lisa C Romero, Thanh V Nguyen, Benoit Deville, Oluwasanmi Ogunjumo and Anthony A James

    Citation: BMC Bioinformatics 2004 5:83

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  2. Content type: Methodology article

    Due to the high cost and low reproducibility of many microarray experiments, it is not surprising to find a limited number of patient samples in each study, and very few common identified marker genes among di...

    Authors: Hongying Jiang, Youping Deng, Huann-Sheng Chen, Lin Tao, Qiuying Sha, Jun Chen, Chung-Jui Tsai and Shuanglin Zhang

    Citation: BMC Bioinformatics 2004 5:81

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  3. Content type: Database

    Post-translational phosphorylation is one of the most common protein modifications. Phosphoserine, threonine and tyrosine residues play critical roles in the regulation of many cellular processes. The fast gro...

    Authors: Francesca Diella, Scott Cameron, Christine Gemünd, Rune Linding, Allegra Via, Bernhard Kuster, Thomas Sicheritz-Pontén, Nikolaj Blom and Toby J Gibson

    Citation: BMC Bioinformatics 2004 5:79

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  4. Content type: Methodology article

    When DNA microarray data are used for gene clustering, genotype/phenotype correlation studies, or tissue classification the signal intensities are usually transformed and normalized in several steps in order t...

    Authors: Helene H Thygesen and Aeilko H Zwinderman

    Citation: BMC Bioinformatics 2004 5:77

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  5. Content type: Research article

    The increasing number of protein sequences and 3D structure obtained from genomic initiatives is leading many of us to focus on proteomics, and to dedicate our experimental and computational efforts on the cre...

    Authors: Drew Lett, Michael Hsing and Frederic Pio

    Citation: BMC Bioinformatics 2004 5:75

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  6. Content type: Software

    Microarray-based comparative genomic hybridisation (array CGH) is a technique by which variation in relative copy numbers between two genomes can be analysed by competitive hybridisation to DNA microarrays. Th...

    Authors: Junbai Wang, Leonardo A Meza-Zepeda, Stine H Kresse and Ola Myklebost

    Citation: BMC Bioinformatics 2004 5:74

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  7. Content type: Software

    A routine goal in the analysis of microarray data is to identify genes with expression levels that correlate with known classes of experiments. In a growing number of array data sets, it has been shown that th...

    Authors: Yingchun Liu and Markus Ringnér

    Citation: BMC Bioinformatics 2004 5:70

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  8. Content type: Research article

    Rhabdomyosarcoma is a relatively common tumour of the soft tissue, probably due to regulatory disruption of growth and differentiation of skeletal muscle stem cells. Identification of genes differentially expr...

    Authors: Andrea Bisognin, Stefania Bortoluzzi and Gian Antonio Danieli

    Citation: BMC Bioinformatics 2004 5:68

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  9. Content type: Research article

    We have compared 38 isolates of the SARS-CoV complete genome. The main goal was twofold: first, to analyze and compare nucleotide sequences and to identify positions of single nucleotide polymorphism (SNP), in...

    Authors: Gordana M Pavlović-Lažetić, Nenad S Mitić and Miloš V Beljanski

    Citation: BMC Bioinformatics 2004 5:65

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  10. Content type: Methodology article

    The identification of relevant biological features in large and complex datasets is an important step towards gaining insight in the processes underlying the data. Other advantages of feature selection include...

    Authors: Yvan Saeys, Sven Degroeve, Dirk Aeyels, Pierre Rouzé and Yves Van de Peer

    Citation: BMC Bioinformatics 2004 5:64

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  11. Content type: Methodology article

    Microarray data must be normalized because they suffer from multiple biases. We have identified a source of spatial experimental variability that significantly affects data obtained with Cy3/Cy5 spotted glass ...

    Authors: Tristan Mary-Huard, Jean-Jacques Daudin, Stéphane Robin, Frédérique Bitton, Eric Cabannes and Pierre Hilson

    Citation: BMC Bioinformatics 2004 5:63

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  12. Content type: Methodology article

    The usefulness of log2 transformation for cDNA microarray data has led to its widespread application to Affymetrix data. For Affymetrix data, where absolute intensities are indicative of number of transcripts, th...

    Authors: Kellie J Archer, Catherine I Dumur and Viswanathan Ramakrishnan

    Citation: BMC Bioinformatics 2004 5:60

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  13. Content type: Research article

    Computational gene prediction continues to be an important problem, especially for genomes with little experimental data.

    Authors: Ian Korf

    Citation: BMC Bioinformatics 2004 5:59

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  14. Content type: Research article

    Transcriptional regulation is a key mechanism in the functioning of the cell, and is mostly effected through transcription factors binding to specific recognition motifs located upstream of the coding region o...

    Authors: Davide Corà, Ferdinando Di Cunto, Paolo Provero, Lorenzo Silengo and Michele Caselle

    Citation: BMC Bioinformatics 2004 5:57

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  15. Content type: Research article

    It is well known that different species have different protein domain repertoires, and indeed that some protein domains are kingdom specific. This information has not yet been incorporated into statistical met...

    Authors: Lachlan Coin, Alex Bateman and Richard Durbin

    Citation: BMC Bioinformatics 2004 5:56

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  16. Content type: Software

    The Distributed Annotation System (DAS) allows merging of DNA sequence annotations from multiple sources and provides a single annotation view. A straightforward way to establish a DAS annotation server is to ...

    Authors: Vincent Negre and Christoph Grunau

    Citation: BMC Bioinformatics 2004 5:55

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  17. Content type: Software

    The detection of small yet statistically significant differences in gene expression in spotted DNA microarray studies is an ongoing challenge. Meeting this challenge requires careful examination of the perform...

    Authors: Jeffrey P Townsend

    Citation: BMC Bioinformatics 2004 5:54

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  18. Content type: Methodology article

    Several aspects of microarray data analysis are dependent on identification of genes expressed at or near the limits of detection. For example, regression-based normalization methods rely on the premise that m...

    Authors: Igor Dozmorov, Nicholas Knowlton, Yuhong Tang and Michael Centola

    Citation: BMC Bioinformatics 2004 5:53

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  19. Content type: Software

    An increasing number of whole viral and bacterial genomes are being sequenced and deposited in public databases. In parallel to the mounting interest in whole genomes, the number of whole genome analyses softw...

    Authors: Srikanth Celamkoti, Sashidhara Kundeti, Anjan Purkayastha, Raja Mazumder, Charles Buck and Donald Seto

    Citation: BMC Bioinformatics 2004 5:52

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  20. Content type: Research article

    To examine interactions among the angiotensin converting enzyme (ACE) insertion/deletion, plasminogen activator inhibitor-1 (PAI-1) 4G/5G, and tissue plasminogen activator (t-PA) insertion/deletion gene polymorph...

    Authors: Christopher S Coffey, Patricia R Hebert, Marylyn D Ritchie, Harlan M Krumholz, J Michael Gaziano, Paul M Ridker, Nancy J Brown, Douglas E Vaughan and Jason H Moore

    Citation: BMC Bioinformatics 2004 5:49

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  21. Content type: Software

    Once specific genes are identified through high throughput genomics technologies there is a need to sort the final gene list to a manageable size for validation studies. The triaging and sorting of genes often...

    Authors: Guohui Zhou, Xinyu Wen, Hang Liu, Michael J Schlicht, Martin J Hessner, Peter J Tonellato and Milton W Datta

    Citation: BMC Bioinformatics 2004 5:46

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  22. Content type: Methodology article

    Computer programs for the generation of multiple sequence alignments such as "Clustal W" allow detection of regions that are most conserved among many sequence variants. However, even for regions that are equa...

    Authors: Olga V Matveeva, Brian T Foley, Vladimir A Nemtsov, Raymond F Gesteland, Senya Matsufuji, John F Atkins, Aleksey Y Ogurtsov and Svetlana A Shabalina

    Citation: BMC Bioinformatics 2004 5:44

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  23. Content type: Software

    The explosion in biological information creates the need for databases that are easy to develop, easy to maintain and can be easily manipulated by annotators who are most likely to be biologists. However, depl...

    Authors: J Daniel Navarro, Naveen Talreja, Suraj Peri, BM Vrushabendra, BP Rashmi, N Padma, Vineeth Surendranath, Chandra Kiran Jonnalagadda, PS Kousthub, Nandan Deshpande, K Shanker and Akhilesh Pandey

    Citation: BMC Bioinformatics 2004 5:43

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  24. Content type: Research article

    To identify differentially expressed genes across experimental conditions in oligonucleotide microarray experiments, existing statistical methods commonly use a summary of probe-level expression data for each ...

    Authors: Leah Barrera, Chris Benner, Yong-Chuan Tao, Elizabeth Winzeler and Yingyao Zhou

    Citation: BMC Bioinformatics 2004 5:42

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  25. Content type: Research article

    Alternative splicing is an efficient mechanism for increasing the variety of functions fulfilled by proteins in a living cell. It has been previously demonstrated that alternatively spliced regions often compr...

    Authors: Marc N Offman, Ramil N Nurtdinov, Mikhail S Gelfand and Dmitrij Frishman

    Citation: BMC Bioinformatics 2004 5:41

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  26. Content type: Software

    We present Pegasys – a flexible, modular and customizable software system that facilitates the execution and data integration from heterogeneous biological sequence analysis tools.

    Authors: Sohrab P Shah, David YM He, Jessica N Sawkins, Jeffrey C Druce, Gerald Quon, Drew Lett, Grace XY Zheng, Tao Xu and BF Francis Ouellette

    Citation: BMC Bioinformatics 2004 5:40

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  27. Content type: Methodology article

    SNP genotyping typically incorporates a review step to ensure that the genotype calls for a particular SNP are correct. For high-throughput genotyping, such as that provided by the GenomeLab SNPstream® instrument...

    Authors: Ching Yu Austin Huang, Joel Studebaker, Anton Yuryev, Jianping Huang, Kathryn E Scott, Jennifer Kuebler, Shobha Varde, Steven Alfisi, Craig A Gelfand, Mark Pohl and Michael T Boyce-Jacino

    Citation: BMC Bioinformatics 2004 5:36

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2018 Journal Metrics

  • Citation Impact
    2.511 - 2-year Impact Factor
    2.970 - 5-year Impact Factor
    0.855 - Source Normalized Impact per Paper (SNIP)
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