Figure 2

Relationship between the correspondence of ligand pharmacophores and their distance from the structural motif on the protein. The list of matching pharmacophores was sorted according to their distance from the centroid of the structural motif. This sorted list was then divided in nine bins of 50 pharmacophores each. The value on the x axis represents the average distance in each bin (the bars represent the standard error). The value on the y axis is the ratio of the number of pharmacophore pairs with comparable chemical roles to the total number of pharmacophore pairs in each bin.