BMC Bioinformatics

Table 2 Performance of MOPHY in capturing the topology of underlying phylogeny for simulated networks.

From: Phylogenetic analysis of modularity in protein interaction networks

*Most Specific Modules*
	Diameter
	2			3			4
Coverage	M OPHY	Random	p -value	M OPHY	Random	p -value	M OPHY	Random	p -value
20%	1.6**	11.2	0.0039	1.6**	11.2	0.0039	1.6**	12.0	0.0029
40%	1.6**	12.0	0.0013	1.6**	10.8	0.0093	1.6**	12.0	0.0014
60%	1.6**	11.2	0.0019	1.6**	11.6	0.0039	1.6**	11.6	0.0021
*Most Comprehensive Modules*
	Diameter
	2			3			4
Coverage	M OPHY	Random	p -value	M OPHY	Random	p -value	M OPHY	Random	p -value
20%	2.4**	11.6	0.0048	2.8**	10.8	0.0088	4.4*	10.8	0.0121
40%	2.8**	12.0	0.0036	2.8**	10.8	0.0032	4.4*	10.4	0.0179
60%	1.6**	10.8	0.0062	2.4**	11.2	0.0029	3.6**	10.0	0.0054

Performance of MOPHY in capturing the topology of underlying phylogeny for simulated networks. For each parameter setting, the symmetric distance between the underlying tree and the tree reconstructed by MOPHY/randomized method is shown. Reported values are averages over five runs. p-values indicate the statistical significance of the performance difference between MOPHY and the randomized method. **: p < 0.01, *: p < 0.05.

Back to article page

ISSN: 1471-2105

Contact us

General enquiries: journalsubmissions@springernature.com