Figure 3

Protein structures colored according to their residue annotation. Example of the isoforms for the gene ENSG00000104870 (IgG receptor FcRn large subunit p51 precursor): the same isoform (a, c) is aligned using CLUSTALW to two other different isoforms (b, d) of the same gene. The parts conserved between the two aligned isoforms are colored in green, the residues conserved only in one isoform are colored in blue (the first and last residue of the insertion are colored in red in the other isoform), and the different mismatches between the two sequences are depicted in other colors, based on whether the substitution has a positive or negative value in the BLOSUM62 matrix. The images are obtained with PyMOL http://www.pymol.org/.