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Figure 7 | BMC Bioinformatics

Figure 7

From: Inferring novel disease indications for known drugs by semantically linking drug action and disease mechanism relationships

Figure 7

Example of one shortest path associating Tamoxifen and SLE exploited from SLE-Tamoxifen network. (a): An association between drug Tamoxifen and disease SLE derived from using DDCO-guided RDF query and inferencing. Arrowed line denotes the connection path between data instances. Red dotted line shows the transitive association inferred from using rulebases in the model. (b): Schematic view showing the graphic relations between GO terms: GO_0006915 (annotation for Gene_5133) and GO_0000008633 (annotation for Gene_207). Using the transitive inference rules created in the rulebases, the association between Gene_5133 and Gene_207 is inferred.

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BMC Bioinformatics

ISSN: 1471-2105

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