From: Annotation of protein residues based on a literature analysis: cross-validation against UniProtKb
 |  | Annotation | |
---|---|---|---|
Example | Sentence | Manual | GO |
1 | "The catalytic mechanism of the non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase and the other aldehyde dehydrogenases resembles a thioester mechanism involving the universally conserved cysteine 298 (pea GAPN)." (PMID:9461340) | thioester mechanism, conserved cysteine | glyceraldehyde-3-phosphate dehydrogenase (NADP+)(phosphorylating activity), glyceraldehyde-3-phosphate biosynthesis, glyceraldehyde-3-phosphate catabolism, phosphoglycerate dehydrogenase activity |
2 | "However, mutations of a key residue, His48, show significant deviation from the relationship, implying a role for the side chain in protection of the complex from hydroxide attack." (PMID:2690955) | protection of the complex from hydroxide attack | AT DNA binding, tRNA, tyrosine tRNA ligase activity |
3 | "Second, this reactive cysteinyl residue, which is required for L-cysteine desulfurization activity, was identified as Cys325 by the specific alkylation of that residue and by site-directed mutagenesis experiments." (PMID:81615929) | L-cysteine desulfurization activity | pyridoxal biosynthesis, phosphate binding, mutagenesis, nitrogenase activity, L-alanine biosynthesis, pyridoxal phosphate binding |