Table 2 Feature weights for siRNA design derived from multi-task learning
From: Multi-task learning for cross-platform siRNA efficacy prediction: an in-silico study
No. | Feature | Weight |
|---|---|---|
1 | position-dependent nucleotide consensus: sum | 0.1954 |
2 | Δ G difference between positions 1 and 18 | 0.0987 |
3 | Δ G of sense-antisense siRNA duplexes | 0.0774 |
4 | position-dependent nucleotide consensus: preferred | 0.0733 |
5 | preferred dinucleotide content index | 0.0726 |
6 | local target mRNA stabilities (Δ G) | 0.0651 |
7 | position-dependent nucleotide consensus: avoided | 0.0640 |
8 | nucleotide content: U | 0.0603 |
9 | stability (Δ G) of dimers of siRNAs antisense strands | 0.0537 |
10 | stability profile for each two neighboring base pairs in the siRNA sense-antisense in position 1 | 0.0384 |
11 | siRNA antisense strand intra-molecular structure stability (Δ G) | 0.0327 |
12 | avoid dinucleotide content index | 0.0324 |
13 | stability profile for each two neighboring base pairs in the siRNA sense-antisense in position 13 | 0.0298 |
14 | stability profile for each two neighboring base pairs in the siRNA sense-antisense in position 18 | 0.0279 |
15 | nucleotide content: G | 0.0267 |
16 | stability profile for each two neighboring base pairs in the siRNA sense-antisense in position 2 | 0.0222 |
17 | stability profile for each two neighboring base pairs in the siRNA sense-antisense in position 6 | 0.0159 |
18 | stability profile for each two neighboring base pairs in the siRNA sense-antisense in position 14 | 0.0138 |
19 | frequency of potential targets for siRNA | 0.0000 |