Figure 2

Three novel biologically significant sequence motifs. Basic statistics and structural/functional annotation for the a) A- [AS]- [FIV]- [NR]-A-P-L- [AT]-G-I motif; b) [WY]-x(2)-Y-P-P-L motif and c) L-x-S-I- [GP] motif. The Abundance field refers to the number of motif hits in the transmembrane proteins in the Swiss-Prot database: a number less than 100 is considered as low, between 100 and 500 as medium and higher than 500 as high. The Specificity field refers to the false positive rate associated to the motif (see Materials and Methods for details). A value of 10% indicates a high specificity, between 10% and 40% a medium specificity and above 40% a low specificity. For each motif a web-logo picture is shown, together with a schematic representations of the associated hydrogen bond patterns. For each motif, a structure multiple alignment of fragments containing the motif is also shown.