Figure 14

Correlation plots between the integral sensitivity of the positional dependent NN-model and solution free energies of DNA/DNA- and DNA/RNA-hybridizations taken from [26, 46] and [28], respectively. The three panels refer to DNA/DNA (ENCODE) and DNA/RNA (mouse, HG133A_S) hybridizations. The integral sensitivities are calculated using either all sequence positions (circles) or positions 3 - 24 (crosses). The latter data are normalized using the normalization factor 24/21 for direct comparison with the former data. Regression lines are shown for the latter data. The regression coefficients (R) and the slopes are given in the figure. The values in parentheses refer to the reduced sum. Note that the integral sensitivities of GG nearest neighbor motifs clearly decrease if one neglects the first two sequence positions. The effect on the regression remains however small. Selected NN motifs are assigned in the figure.