Table 5 Brief description and comments on some genes (of datset-1) found to be differentially expressed and associated with RhoG from literature.
From: Bayesian integrated modeling of expression data: a case study on RhoG
Gene | Comment | Fold change(natural scale) | Pubmed Id (PMID) | Posterior probabilities |
|---|---|---|---|---|
ARHGEF3 | ARHGEF3 form complex with G proteins and stimulate Rho-dependent signals. | 2.2 | 12221096 | p+ = 1 |
ICAM1 | ICAM1 binds to integrins of type CD11a/CD18, or CD11b/CD18 and stimulates intercellular signaling. | 1.6 | 17875742 | p+ = 0.9913 |
IL6 | IL6 is an immunoregulatory cytokine that activates a cell surface signaling assembly composed of IL6, IL6RA, and the shared signaling receptor gp130. | 4.2 | 15578470 | p+ = 1 |
JUN | This gene encodes a protein which interacts directly with specific target DNA sequences to regulate gene expression. | 1.8 | 12739001, 1620121, 9671479, 10744696 | p+ = 0.9935 |
NFKB1 | NFKB is a transcription regulator that is activated by various intra-and extra-cellular stimuli. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. | 1.9 | 12670394, 11803464, 12376551 | p+ = 0.9942 |
NISCH | NISCH is involved in the regulation of cell migration and cell invasion. | 1.9 | 12890925 | p+ = 0.9965 |
PCNA | PCNA is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein helps increase the processivity of leading strand synthesis during DNA replication. | 0.76 | 12167123 | p- = 1 |
PTGS2 | Prostaglandin-endoperoxide synthase is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. | 2.3 | 10974444 | p+ = 1 |
RHOF | RHOF functions cooperatively with CDC42 and Rac to generate filopodia increasing the diversity of actin-based morphology. | 3.7 | 15894457 | p+ = 0.9994 |