Figure 1

Distance matrix. The matrix shows the results of all-to-all comparisons. The 9 ligands are indicated along the rows and columns and the proteins binding each ligand are grouped together. The grid of horizontal and vertical black lines separates different groups of proteins. The matrix is color-coded from 0 (blue) to 1 (red), with red corresponding to high number of aligned atoms and therefore high similarity in the shape of the binding sites and blue to the lowest degree of similarity.