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Table 1 Results for synthetic 10-mix spectrum with overlapping peptides

From: BPDA - A Bayesian peptide detection algorithm for mass spectrometry

 

BPDA

OpenMS

True Mass (Da)/Intn/CS

dM (Da)/Intn/CS

dM (Da)/Intn/CS

1264.279/0.034/1-3

-0.0065/0.032/1-3

NA

1266.383/0.103/1-3

-0.0025/0.110/1-3

-0.0025/0.156/1-3

1382.247/0.171/1-4

0.0028/0.181/1-4

0.0031*/0.228/1-3

1388.367/0.114/1-4

-0.0073/0.097/1-4

-0.0046/0.150/1-3

1293.323/0.006/1-3

-0.0081/0.007/1-2

NA

1294.345/0.008/1-3

-0.0124/0.008/1-3

0.0033/0.018/1-2

1312.441/0.229/1-4

0.0018/0.247/1-4

0.0019*/0.334/1-4

1313.451/0.183/1-4

-0.0061/0.173/1-4

NA

1327.386/0.080/1-4

-0.0035/0.067/1-3

0.0061*/0.114/1-3

1329.378/0.072/1-4

-0.0035/0.078/1-4

NA

  1. Results for the 10-mix data set. Intn, CS and dM denote the normalized intensity, detectable charge states and the mass deviation from the true mass, respectively. When FPR = 0.1, BPDA was able to detect all 10 true peptides, while OpenMS detected only 3 peptides (marked by *). OpenMS achieved its highest TPR (0.6) when FPR = 0.3.
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BMC Bioinformatics

ISSN: 1471-2105

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