Figure 2

Differentially coexpressed modules between carcinogen-treated Eker rats and wild-type rats. Panel A: Comparative correlation heat map. The upper diagonal of the main matrix shows a correlation between pairs of genes among the Eker mutant rats (the red color corresponds to positive correlations, blue to negative correlations). The lower diagonal of the heat map shows a correlation between the same gene pairs in the wild-type controls. Modules are identified in the heat map by black squares and on the right side of the heat map by a color bar. The brown bands on the right side indicate the mean expression of the modules in the Eker rats (first column) and the wild-type rats (second column); darker colors indicate higher mean expression levels. Panel B: Expression variation (scaled) in the Eker mutants (left) and the wild-type rats (right) of the genes in the yellow module which are annotated in KEGG with "pancreatic cancer". In the Eker rats the variation of these genes is tightly correlated, whereas for the wild-type rats it is much more random.