Figure 6

Induced fit phenomena differentiates structures belonging to the same MMP class. Elucidation of differences between PDB:1CGL with PDB:1CGE and PDB:1CGF when comparing S₃-S₁-S₃' regions. The Asn80 residue is coloured yellow for the apo-proteins (PDB:1CGF and PDB:1CGE) and cyan for the complex (PDB:1CGL) co-crystallised with a peptide inhibitor rendered as green sticks. The coordination of zinc with the three catalytic histidines and carboxylic group of the ligand is highlighted.