Predicting success of oligomerized pool engineering (OPEN) for zinc finger target site sequences

BMC Bioinformatics

Table 1 Performance of classifiers in predicting active OPEN target sites

Classifier	Target site encoding	ROC AUC	Correlation Coefficient	Accuracy %	Specificity⁺%	Sensitivity⁺%
Naïve Bayes	ZiFOpT (Sequence Identity)	0.89	0.61	87	90	94
	Base Counts	0.79	0.57	87	89	94
	Positional Base Counts	0.84	0.59	87	88	97
SVM	Sequence Identity	0.76	0.48	84	86	95
	Base Counts	0.78	0.54	85	89	92
	Positional Base Counts	0.84	0.63	88	90	95

ISSN: 1471-2105