Validation and characterization of DNA microarray gene expression data distribution and associated moments

BMC Bioinformatics

Table 5 Coefficients of the quadratic trends between the kurtosis and skewness of the distribution of the logarithm of gene expression for each of the three data sets.

*Data set*	Constant	Linear	Quadratic	R²
Craniofacial	2.96 ± 0.04	-0.31 ± 0.07	1.40 ± 0.03	0.91
Liver	3.30 ± 0.07	0.12 ± 0.10	1.42 ± 0.06	0.58
Brain	2.97 ± 0.03	0.03 ± 0.03	1.31 ± 0.03	0.65
Male	3.65 ± 0.34	-0.05 ± 0.27	1.21 ± 0.07	0.82
Female	3.85 ± 0.27	-0.12 ± 0.20	1.23 ± 0.05	0.89

Also included in the table are the 95% confidence intervals for these coefficients, the coefficient of determination, R² and the p-value for the goodness of fit F-test to the linear model. Note that the models are computed using data over those probe sets with mean expression greater than 6 in order to avoid analysis with noisy or low expression genes.

ISSN: 1471-2105