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Table 3 Predicted Rearrangments involving PTPN12 in GBM.

From: Detection of recurrent rearrangement breakpoints from copy number data

 

Recurrent Gene PTPN12

  

Gene

Genomic Location

# Patients

PTPN12

chr7.77004708-77106533

16

 

Intrachromosomal Fusion Gene Predictions

  

5' End Gene

3' End Gene

# Patients

RMS

PTPN12

chr7.77005287-77106533

RSBN1L

chr7.77163678-77246421

8

0.1081

PTPN12

chr7.77004708-77106533

LUC7L2

chr7.138695173-138757626

8

0.2605

 

Interchromosomal Fusion Gene Predictions

  

5' End Gene

3' End Gene

# Patients

RMS

TMEM30A

chr6.76019357-76051074

PTPN12

chr7.77005287-77106533

6

0.1306

RNF150

chr4.142006174-142273412

PTPN12

chr7.77005287-77106533

5

0.1409

PTPN12

chr7.77005287-77106533

MED13

chr17.57374747-57497348

9

0.1906

CLK1

chr2.201425977-201434830

PTPN12

chr7.77005287-77106533

8

0.3168

ZRANB2

chr1.71301561-71319266

PTPN12

chr7.77005287-77106533

9

0.3250

PTPN12

chr7.77005287-77106533

UBR1

chr15.41022389-41185512

9

0.3475

PTPN12

chr7.77005287-77106533

LINGO1

chr15.75692423-75711712

8

0.3787

PPIL3

chr2.201443923-201460583

PTPN12

chr7.77004708-77106533

6

0.4741

  1. The phosphatase PTPN12 appears in 10 predicted fusion genes, and is also a predicted gene truncation for 16 patients. The predictions are ranked according to the root mean squared difference (RMS) of the copy number on either side of the fusion point.