BMC Bioinformatics

Table 2 Simulated FDR and Power Rate (10 Analyses)

From: Sequential interim analyses of survival data in DNA microarray experiments

	Analysis
	1		2		3		4		5
	mean	sd	mean	sd	mean	sd	mean	sd	mean	sd
#found genes	0	0	10	85	164	437	1033	928	2404	915
FDR	0.003	0.055	0.029	0.119	0.048	0.145	0.034	0.061	0.028	0.006
APR	0.000	0.000	0.002	0.016	0.032	0.085	0.200	0.180	0.467	0.178
	0.043	0.060	0.038	0.120	0.049	0.134	0.241	0.208	0.518	0.174
(S)	0.055	0.122	0.025	0.085	0.037	0.092	0.220	0.188	0.488	0.172
(L)	0.283	0.401	0.382	0.228	0.410	0.132	0.581	0.113	0.708	0.079
	6		7		8		9		10
	mean	sd	mean	sd	mean	sd	mean	sd	mean	sd
#found genes	3414	637	3894	520	4092	471	4155	451	4167	446
FDR	0.027	0.004	0.027	0.004	0.027	0.004	0.027	0.004	0.027	0.004
APR	0.664	0.124	0.757	0.101	0.796	0.092	0.808	0.088	0.811	0.087
	0.698	0.096	0.778	0.062	0.812	0.043	0.823	0.034	0.825	0.031
(S)	0.671	0.117	0.756	0.098	0.790	0.091	0.802	0.087	0.804	0.086
(L)	0.797	0.056	0.847	0.042	0.870	0.031	0.877	0.025	0.878	0.023

The descriptive values for each interim analysis including the number detected genes, the simulated FDR, the real APR, and the APR estimates, all in the setting of τ = 50% altered genes with large fold changes and ten interim analyses. These values correspond to Figure 4 (b) and Figure 5 (b).

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ISSN: 1471-2105

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