BMC Bioinformatics

Table 5 Simulated FDR and Power Rates (Parameters from the Breast Cancer Data)

From: Sequential interim analyses of survival data in DNA microarray experiments

	Analysis
	1		2		3		4		5
	mean	sd	mean	sd	mean	sd	mean	sd	mean	sd
#found genes	0	0	0	0	14	34	701	227	1650	396
FDR	0.000	0.000	0.000	0.000	0.074	0.179	0.035	0.008	0.034	0.005
APR	0.000	0.000	0.000	0.000	0.002	0.004	0.079	0.026	0.186	0.045
	0.000	0.000	0.100	0.160	0.004	0.008	0.117	0.031	0.234	0.044
(S)	0.000	0.000	0.118	0.238	0.003	0.007	0.107	0.029	0.217	0.043
(L)	0.000	0.000	0.443	0.374	0.371	0.032	0.514	0.030	0.591	0.029
	6		7		8		9		10
	mean	sd	mean	sd	mean	sd	mean	sd	mean	sd
#found genes	2005	413	2318	457	2614	442	2906	447	3107	439
FDR	0.034	0.005	0.033	0.005	0.033	0.005	0.034	0.004	0.033	0.004
APR	0.227	0.046	0.262	0.051	0.296	0.050	0.329	0.050	0.352	0.050
	0.275	0.046	0.308	0.050	0.341	0.048	0.371	0.048	0.392	0.046
(S)	0.259	0.046	0.289	0.051	0.324	0.049	0.354	0.050	0.375	0.051
(L)	0.617	0.029	0.631	0.029	0.648	0.029	0.664	0.030	0.675	0.032

The descriptive values for each interim analysis including the number detected genes, the simulated FDR, the real APR, and the APR estimates, all in the setting where parameters were taken from the breast cancer data.

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