HomPPI: a class of sequence homology based protein-protein interface prediction methods

BMC Bioinformatics

Table 2 Interface Residue Prediction Performance of NPS-HomPPI on Benchmark180.

Binding Type	Homology Zone	Prediction Coverage	CC^P	Sensitivity^P	Specificity^P	Accuracy^P
Enzyme-inhibitor,- Transient	Safe/Twilight	67% (24/36)	0.53	0.67	0.58	0.86
Non-enzyme-inhibitor-Transient (NEIT)	Safe/Twilight	60% (18/30)	0.45	0.54	0.58	0.83
Hetero-dimer - Obligate	Safe/Twilight	85% (23/27)	0.63	0.72	0.69	0.88
Homo-dimer - Obligate	Safe/Twiight	69% (60/87)	0.76	0.83	0.78	0.94

Prediction coverage reflects that predictions are made only on proteins for which HomPPI can identify Safe/Twilight Zone homologs.

ISSN: 1471-2105