Figure 5

The experimentally-derived B cell-specific disease signature is significantly correlated with the B cell subset-specific signature across a population of SLE patients. Enrichment scores were calculated for each patient (points) using either the B cell subset-specific signature from SPEC (x axis) or the B cell-specific disease signature produced using data from experimentally purified B cells (see methods). The sample correlation between these enrichment scores is r = 0.73, which is significantly higher than the correlation of the subset signature with randomly generated signatures (p < 0.05).