Figure 4

Residue selection for the ADRB2 receptor. A: Plot of the entropy within the ADRB2 receptor subfamily versus outside the subfamily. Lines are drawn at equal score and residues disrupting ligand binding upon mutation are colored green. B: Crystal structure of ADRB2 co-crystalized with carazolol (pdbid: 2RH1), residues disrupting ligand binding upon mutation are colored green. C: Receiver Operator Characteristic (ROC) curve showing the ability of ss-TEA to select ligand binding residues compared to random selection. D: ROC curve with logarithmic x-axis.