Figure 1From: The representation of protein complexes in the Protein Ontology (PRO)Schematic showing the relationships between UniProtKB, ProForm, GO, and ProComp. Arrows between ProForm and UniProtKB are xref, those between ProComp and ProForm are has_part, and between ProComp and Gene Ontology the arrows depict is_a relationships. In ProForm each protein form is assigned a unique identifier and is cross-referenced to protein entries in UniProtKB. Protein isoforms and modified forms are described in UniProtKB records, but in contrast to PRO, each protein form is not represented as a separate, uniquely accessioned entity in UniProtKB. For example, for the alpha subunit of IDH in mouse there is a PRO entry for the protein (PR:000025358) and for each of the alpha protein isoforms (PR:000025355 and PR:000025356). In UniProt the IDH alpha subunit and its isoforms are all represented in the same record (UniProt: Q9D6R2). In ProComp, accessioned, species-specific protein complex entities are described using protein entries from ProForm. The protein complexes in ProComp are cross-referenced to species-independent complex representations in the Gene Ontology (GO).Back to article page