Multilocus association mapping using generalized ridge logistic regression

BMC Bioinformatics

Table 5 Results for AMD Hong Kong data using logistic regression

*Rank*	*Chr*	*SNP rs#*	*Bp Position*	*Odds Ratio*	*Original P-value*	*Bonferroni Correction*	*Empirical P-value*
1	10	rs 10490924	124204438	0.26	1.25E-09	0.0001	0.001
2	8	rs 10504152	54292668	0.18	5.45E-06	0.4428	0.062
3	7	rs 10499342	4340896	0.36	3.88E-05	1.0000	0.550
4	13	rs 2011847	69496879	0.42	5.86E-05	1.0000	0.738
5	8	rs 1377131	53838124	3.09	7.49E-05	1.0000	0.836
6	4	rs 10520462	182400252	3.21	8.73E-05	1.0000	0.888
7	1	rs 1564485	53333649	0.41	1.10E-04	1.0000	0.940
8	5	rs 10521010	33931083	3.03	1.17E-04	1.0000	0.943
9	5	rs 251610	65314237	0.45	1.55E-04	1.0000	0.980
10	20	rs 1858597	95685	0.42	1.66E-04	1.0000	0.987

Analysis results for the published dataset on AMD Hong Kong using logistic regression. Odds ratios, original p-values, p-values after Bonferroni correction, and empirical p-values (derived from 1000 permutations) of the top 10 SNPs are listed.

ISSN: 1471-2105