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Table 4 Prioritization with ProDiGe4 for 8 diseases with only 2 known genes

From: ProDiGe: Prioritization Of Disease Genes with multitask machine learning from positive and unlabeled examples

Disease name

MIM Id

Training ∩ IPA

Precision (%)

Recall (%)

P-value

Glaucoma

606657

2

8

12.5

2.0e-11

Creutzfeld-Jacob

123400

2

2

40.0

1.3e-06

Hyperparathyroidism

145000

2

3

18.7

1.1e-06

Psoriasis

177900

2

4

6.0

1.8e-05

Glioblastoma

137800

2

16

10.7

8.4e-19

Cystic fibrosis

219700

2

5

10.6

9.3e-08

Pancreatic carcinoma

260350

1

8

9.6

2.3e-10

Thalassemia

604131

0

2

25.0

2.6e-06

  1. The results were validated by comparing our top 100 genes with a list of genes related to the disease, extracted from Ingenuity database.
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BMC Bioinformatics

ISSN: 1471-2105

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