Figure 2
From: Dr. PIAS: an integrative system for assessing the druggability of protein-protein interactions
Screenshots of Dr. PIAS. (A) Top page of Dr. PIAS. (B) 'Advanced search' form. (C) Main search result summarizing PPIs and their druggability scores. (D) PPI network derived from a search result of Dr. PIAS. The network is drawn using the software eXpanda [48]. (E) Example of potential ligand-binding pocket on a PPI interface, which was used for assessing the druggability of a PPI. The pocket is shown by atoms colored red. The image is generated using the software Jmol [49]. (To see the pocket information, click the header 'structural information' in the main search result table, then click the header '# protein complexes in PDB' in the 'Structural information' table in a new window/tab opened, and then click '[pocket]' after the list of PDB entry names in the 'PDB information' table in a new window/tab opened.)