Skip to main content
Figure 5 | BMC Bioinformatics

Figure 5

From: Hsp90/Cdc37 Chaperone/co-chaperone complex, a novel junction anticancer target elucidated by the mode of action of herbal drug Withaferin A

Figure 5

H-bonding interactions present in the docked complex of withaferin A with active Hsp90/Cdc37 complex using flexible docking. Polar hydroxyl terminal group of withaferin A captivates amino group of Gln 208 of Cdc37 to form H-bond with itself, thus disrupting the earlier present Gln 208 - Ser 113H-bond. WA also disrupts the H-bond between Gln 133-Arg 166 by forming H-bond with Arg 166 of Cdc37. WA also forms H-bonds with Asp 54 and Asp 106 of Hsp90.

Back to article page

BMC Bioinformatics

ISSN: 1471-2105

Contact us