Table 2 Description of warnings and their frequencies.

Criterion 2: validation of biologically correct models

Cardinality constraint

1. The number of input/inputprocess/output entities is not correct.

2. The inputprocess/output entities are not defined.

Type constraint

3. TYPE of entity is wrong/not defined.

Property constraint

4. CELLCOMPONENT is not correct/not given.

5. FEATURETYPE is not defined.

6. STOICHIOMETRY is not correct.

7. UNIFICATIONXREF is not defined.

Property relationship constraint

8. The values of CELLCOMPONENT that should be different are the same.

Criterion 3: validation of systematically correct models

9. Starting complex that needs to add a binding process.

10. Starting entity that needs to add a unknown production process.

11. Degrading entity that needs to add a unknown degradation process.