Table 1 Core genes of the TCA cycle and glycolysis
From: Analysis of cancer metabolism with high-throughput technologies
Gene name | Gene ID | mRNA accession number | Pathway | Copy Number of Transcript | |
|---|---|---|---|---|---|
UHRR | HBRR | ||||
CS (Citrate synthase) | 1431 | NM_004077 | TCA cycle | 11.2 | 7.4 |
ACO2 (Aconitase 2) | 50 | NM_001098 | TCA cycle | 7.8 | 20.7 |
IDH2 (isocitrate dehydrogenase 2) | 3418 | NM_002168 | TCA cycle | 13.1 | 6.2 |
OGDH (oxoglutarate dehydrogenase) | 4967 | NM_001165036 | TCA cycle | 2.8 | 3.3 |
SUCLA2 (succinate-CoA ligase) | 8803 | NM_003850 | TCA cycle | 1.1 | 2.1 |
SDHA (succinate dehydrogenase complex, sub. A) | 6389 | NM_004168 | TCA cycle | 20.5 | 15.4 |
FH (fumarate hydratase) | 2271 | NM_000143 | TCA cycle | 6.5 | 2.8 |
MDH1 (malate dehydrogenase 1) | 4190 | NM_005917 | TCA cycle | 10.4 | 26.2 |
HK1 (hexokinase 1) | 3098 | NM_033500 | Glycolysis | 2.3 | 3.0 |
GPI (glucose-6-phosphate isomerase) | 2821 | NM_000175 | Glycolysis | 11.9 | 10.3 |
PFKL (phosphofructokinase, liver) | 5211 | NM_002626 | Glycolysis | 21.7 | 10.3 |
ALDOA (aldolase A, fructose-bisphosphate) | 226 | NM_000034 | Glycolysis | 49.9 | 25.0 |
TPI1 (triosephosphate isomerase 1) | 7167 | NM_001159287 | Glycolysis | 68.4 | 29.8 |
GAPDH (glyceraldehyde-3-phosphate dehydrogenase) | 2597 | NM_002046 | Glycolysis | 886.6 | 287.3 |
PGK1 (phosphoglycerate kinase 1) | 5230 | NM_000291 | Glycolysis | 67.4 | 15.1 |
PGAM1 (phosphoglycerate mutase 1) | 5223 | NM_002629 | Glycolysis | 41.5 | 27.6 |
ENO1 (enolase 1) | 2023 | NM_001428 | Glycolysis | 264.2 | 51.3 |
PKM2 (pyruvate kinase) | 5315 | NM_002654 | Glycolysis | 37.7 | 21.3 |