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Table 12 Performance of the proposed algorithm when p 53 is deactivated and Mdm 2 is amplified.

From: Probabilistic reconstruction of the tumor progression process in gene regulatory networks in the presence of uncertainty

p 1

# networks

# network-path pairs

# paths

result

# SSD calculations

p1 = 0.1

1063

1629

4

F

40,016

p1 = 0.3

1661

2582

4

F

48,038

p1 = 0.5

2704

4089

4

F

69,146

p1 = 0.7

4096

8839

4

S

101,426

  1. Performance of the proposed algorithm when p 53 is deactivated and Mdm 2 is amplified. Several different values of β1 was used (by varying p1), and β2 was set to 0.1. We assumed that the true perturbation probability is unknown, hence there is a model mismatch (p = 0.003, p cancer = 0.001).
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BMC Bioinformatics

ISSN: 1471-2105

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