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Table 3 Results of Fischer’s randomization test.

From: Development, evaluation and application of 3D QSAR Pharmacophore model in the discovery of potential human renin inhibitors

Validation no.

Total cost

Fixed cost

RMSD

Correlation

Original hypothesis

Hypo1

81.50

70.08

1.080

0.944

Randomized hypotheses

Trial1

95.892

70.080

1.661

0.862

Trial2

100.32

70.212

1.708

0.857

Trial3

92.248

65.837

1.531

0.890

Trial4

87.507

67.786

1.421

0.902

Trial5

93.581

68.931

1.653

0.863

Trial6

89.344

71.436

1.299

0.920

Trial7

87.886

66.944

1.464

0.895

Trial8

101.135

70.080

1.633

0.877

Trial9

98.448

68.674

1.764

0.844

Trial10

94.837

65.837

1.649

0.868

Trial11

99.687

71.629

1.663

0.865

Trial12

91.806

69.736

1.562

0.877

Trial13

107.608

70.080

2.021

0.787

Trial14

92.806

69.736

1.470

0.897

Trial15

101.133

69.688

1.866

0.822

Trial16

87.621

71.436

1.340

0.912

Trial17

90.393

70.212

1.357

0.913

Trial18

84.474

65.837

1.377

0.908

Trial19

98.957

70.268

1.722

0.852