Figure 5

Determining the contribution of gene weighting and moderated t-scores in PADOG performance. The boxplots show the distribution of the target pathways p-value (left panel) and ranks (middle panel), as well as the paired difference in ranks with respect to noMnoW, chosen as reference method (right panel). The lower the p-values, ranks and ranks differences, the better method. PADOG is compared against simpler approaches that i) use gene weights but regular rather than moderated t-scores (noM), ii) use moderated t-scores but no gene weights (noW) and iii) use neither moderated t-scores nor gene weights (noMnoW).