Figure 9

Structural comparison of hDus2 model and the crystal structure of TthDus. In the hDus2 model, domains do not interact with each other and are positioned arbitrary (the N-terminal domain on the right, the C-terminal domain on the left), to facilitate visual analysis of the binding site. For both structures the backbones are shown in the ribbon representation (hDus2 model in grey, TthDus in green), conserved residues in the active site are shown in the sticks representation and labeled (numbering is according to crystal structure only). For clarity of the presentation, each residue is shown in a different color (color scheme as in Figure 7).