Figure 2

DxDxDG structural motifs in a variety of structural contexts. A) Structures of two unrelated hits with pdb ids 1txv (chain A, left), 2z30 (chain A, right) and 1exr (centre), aligned with respect to their common structural motif. B) Expansions of the corresponding structures in A, to clearly show the common structural motif. The backbone rmsd:s of the presented structural motifs to the original configuration in 1exr are 0.33 and 0.26 Å for 1txv and 2z30, respectively. In both A) and B), the residues of each protein that satisfied the motif specification have been coloured red, and the stretches of residues preceding and following the motif have been coloured in yellow and blue, respectively.