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Table 2 Performance of different methods in terms of the AUC

From: Disentangling evolutionary signals: conservation, specificity determining positions and coevolution. Implication for catalytic residue prediction

Method

AUC

AUC0.1

C

0.881

0.491

0.2 C + 0.8 p(C)

0.898

0.553

0.15 C + 0.85 p(rvET62)

0.913

0.567

0.25 C + 0.75 p(MI62)

0.912

0.555

0.15 C + 0.0 p(C) + 0.85 p(rvET62)

0.913

0.567

0.15 C + 0.3 p(C) + 0.55 p(MI62)

0.916

0.571

0.15 C + 0.0 p(C) + 0.45 p(rvET62) + 0.4 p(MI62)

0.921

0.586

  1. Methods give the optimal combined model including conservation and the different proximity scores. The relative weights were determined using fivefold cross validation as described in the text. AUC and AUC0.1 are the average performance values over the 424 protein families.
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BMC Bioinformatics

ISSN: 1471-2105

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