Figure 1From: Visualisation of variable binding pockets on protein surfaces by probabilistic analysis of related structure setsThe difficulties of global comparison of pockets on protein surfaces. (A) Pocket predictions from PASS (red) and LIGSITE-cs (green) for the same interleukin-2 (IL-2) structure (ribbon, PDB:1M47). The similarities and differences between these predictions are readily visualized, but how can identification of common features be automated? (B) Homologous structures: The surface pockets of IL-2 (white ribbon, green spheres) [PDB:1M47] and its distant homologue leukaemia inhibitory factor (LIF) (blue ribbon, blue spheres) [PDB:1LKI], both represented by LIGSITE-cs spheres, show little overlap. Is this because the pockets are genuinely unrelated, or because of the difficulty of making a 'correct' structural alignment?.Back to article page