Figure 2From: Accelerated maximum likelihood parameter estimation for stochastic biochemical systemsComputing time of MCEM versus MCEM2for pure-birth process. Red circles and curve fit depict computing time required for MCEM2 to return MLEs for the pure-birth model with θ ̂ ( 0 ) =1 and varying θ∗ values. Blue circles and curve fit depict identical quantities for ascent-based MCEM. Performance of MCEM2 is robust to the discrepancy between initial and true parameter values, while ascent-based MCEM quickly becomes computationally intractable as the discrepancy increases.Back to article page