Figure 1

A BAR+ cluster with a magnesium binding template. The BAR+ output. When the query is the UniProtKB accession code P15374, the corresponding annotation cluster comprises 213 sequences from Eukaryotes with an average length of 232 residues and 3 PDB structures. Only one of them (human Ubiquitin hydrolase UCH-L3, PDB:1XD3_A) is shown using PyMol (http://www.pymol.org) with the three Mg ions. Of the three ions (as shown in the inset where the PDB SITE fields are reported) only two are coordinated by lateral side chains (in red in the protein structure representation). The cluster contains 26 validated GO terms and 1 validated Pfam term (PF01088, Ubiquitin carboxyl-terminal hydrolase, family 1) that are also inherited by the human query sequence. See text for details.