Figure 4

Structures of subfamily I and II. Structures of subfamily I (top) and II (bottom)are shown for comparison. Colors are consistent with regions in Figure 3. Note the difference in Clasp region, the three loops and the ARS-like region. Subfamily I IDHs have α-helices (β-α-β pattern from each subunit). Subfamily II have all β (β-ββ-β) greek-key motif [57, 58]. Images were made using Chimera [80].