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Figure 4 | BMC Bioinformatics

Figure 4

From: Amino acid function and docking site prediction through combining disease variants, structure alignments, sequence alignments, and molecular dynamics: a study of the HMG domain

Figure 4

A) Amino acids (yellow) located on the backside of the third helix conserved in multiple sequences of Sry not identified in NVs of HMG diseases. B) The amino acids in A are shown on sequence alignments of the human SOX members. C) Proposed docking between the conserved amino acids on Sry (yellow) and the CTE of AR (red). D) MD simulations of the CTE interacting with DNA and SRY (left) or Sox9 (right) either docked (blue), AR mutated to all alanines (green) or pulled away from the interaction and free in movement (red).

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BMC Bioinformatics

ISSN: 1471-2105

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