Figure 12

Beta-lactamase objective function trends. Shown are the objective function trends (left: $\mathrm{\Delta }{\mathsf{\text{G}}}_{\mathsf{\text{nn}}}^{\circ }$; right: f₁ at θ = 9) for beta-lactamase plans with 0 to 10 mutations, for pairs of beta-lactamase parents from (red) E. coli and P. aeruginosa, (blue) P. aeruginosa and B. licheniformis, and (magenta) E. coli and P. mirabilis.