From: Fine-tuning anti-tumor immunotherapies via stochastic simulations
Require: (T0, E0, I0), t0, t stop . |
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1: initialize the simulation as for Algorithm 1; |
2: while t < t stop do |
3: pick a value for Ï„ as in Algorithm 1; |
4: get θ next = min{θ i ∈ Θ | θ i >t} |
5: if τ < θ next then |
6: fire a reaction as in Algorithm 1; |
7: else |
8: update (T, E, I(t)) to (T, E + w next , I(t + θ next )) and change clock to t + θ next ; |
9: end if |
10: end while |