Figure 2

Calreticulin network. Analysis of the calreticulin network shows that not only calreticulin expression is modified in renal graft rejection but also many of the genes/proteins (34%) with known interactions with calreticulin. In addition specific processes/pathways are enriched including extracellular matrix interaction and basement membrane proteins. These are processes and pathways known to be involved in renal graft rejection. Overall projection of the KUPKB data on the calreticulin interaction network clearly exemplifies a role of calreticulin in renal graft rejection.