Figure 3

The IL6/IL6R axis network for human and rat. The IL6/IL6R axis expression network created by querying the KUPNetViz for IL6 and IL6R and using the first level interaction neighbors of IL6. (A) The network associated with IL6/IL6R is mostly up-regulated in patients with PKD as observed after mapping the results of three relevant studies in human (namely “Lai, Proteomics Clin Appl, 2008”, “Mason, Proteomics Clin Appl, 2009” and “Song, Hum Mol Genet, 2009”), (B-D) Progressive upregulation of the IL6/IL6R network in PKD in rat model as derived from the study of Koupepidou et al.[36]. The three figures depict three distinct stages of the disease, specifically (A) day 0, (B) day 6 and (D) day 24, after mapping the three experimental conditions in the dataset “Koupepidou, BMC Nephrol, 2010”.