Figure 4

Liddle syndrome. Mutations in either SCNNB or SCNNG are associated with Liddle syndrome (disease group 772). Both are subunits of the heterotrimeric (alpha, beta, gamma) nonvoltage-gated, amiloride-sensitive, sodium channel. Both proteins were observed together with SCNN1A (the alpha subunit of the channel) as interactors with syntaxin 1A (STX1A). The original paper[32] contains evidence for a direct interaction between STX1A and the gamma subunit and for a complex that includes all four proteins using in-vitro translated components (Figure one in[32]). The complex is represented as four binary interactions in the BioGrid database. These interactions are identified as part of a potential spoke-represented complex by iRefScape (a grey hexagon appears after selecting View Tools/Show spoke-represented complexes from the iRefScape menu).