Table 1 Estimated Type I error rates at significant level 0.05 based on the four methods under different parameter settings of the three-component mixture distributions with τ 1  = 0.1, τ 2  = 0.9 and δ μ  = 0.05
From: Age-adjusted nonparametric detection of differential DNA methylation with case-control designs
Parameter Setting | π 1 | π 2 | π 3 | μ | σ | t-test | Linear regression | Wilcox | BWS |
|---|---|---|---|---|---|---|---|---|---|
1 | 0.3 | 0.5 | 0.2 | 0.3 | 0.1 | 0.0513 | 0.0521 | 0.0514 | 0.0458 |
2 | 0.4 | 0.5 | 0.1 | 0.2 | 0.1 | 0.0495 | 0.0494 | 0.0519 | 0.0492 |
3 | 0.4 | 0.5 | 0.1 | 0.3 | 0.2 | 0.0511 | 0.0519 | 0.0503 | 0.0495 |
4 | 0.5 | 0.1 | 0.4 | 0.3 | 0.2 | 0.0528 | 0.0521 | 0.0544 | 0.0511 |
5 | 0.4 | 0.2 | 0.4 | 0.2 | 0.1 | 0.0509 | 0.0510 | 0.0472 | 0.0464 |