Table 5 Comparison among three different preprocessing techniques when MCODE tool is selected.
Preprocessing Methods | PPI-Network Modification | Protein Complexes | Protein Fraction | P-Value |
|---|---|---|---|---|
Actin Cytoskeleton Organization | ||||
Detect Defective Cliques (Suggested) | Add 1 PPI | abp1, app1, rvs167, act1, ysc84 | 4/6 | 1.93e-05 |
No Preprocessing | --- | abp1, app1, rvs167, act1, yor284w | 3/5 | 8.10e-04 |
Betweenness Centrality | Remove 3 PPI (2 core PPI) | abp1, rvs167, ysc84, yor284w | 2/4 | 7.1e-05 |
Bipolar Cellular Bud Site Selection | ||||
Detect Defective Cliques (Suggested) | Add 1 PPI | sla2, las17 | 2/2 | 5.30e-04 |
No Preprocessing | --- | sla2, las17 | 2/2 | 5.30e-04 |
Betweenness Centrality | Remove 3 PPI (2 core PPI) | --- | --- | --- |
Rho Protein Signal Trasduction | ||||
Detect Defective Cliques (Suggested) | Add 1 PPI | cla4, gic2, cdc42 | 3/3 | 1.76e-06 |
No Preprocessing | --- | cla4, gic2, cdc42 | 3/3 | 1.76e-06 |
Betweenness Centrality | Remove 3 PPI (2 core PPI) | cla4, gic2, cdc42 | 3/3 | 1.76e-06 |