iStable: off-the-shelf predictor integration for predicting protein stability changes

BMC Bioinformatics

Table 10 Evaluation of iStable prediction results with data from different protein superfamilies

Protein categories	Predictors	Sn	Sp	Acc	MCC
Nucleic acid binding
	iStable	0.550	0.943	0.795	0.567
	I-Mutant_PDB	0.550	0.852	0.742	0.439
	I-Mutant_SEQ	0.300	0.943	0.704	0.343
	AUTO-MUTE_RF	0.250	0.971	0.704	0.359
	AUTO-MUTE_SVM	0.250	0.943	0.684	0.262
	MUPRO_SVM	0.450	0.857	0.704	0.395
	PoPMuSiC2.0	0.400	0.910	0.724	0.355
	CUPSAT	0.350	0.552	0.476	-0.073
Enzyme
	iStable	0.451	0.797	0.720	0.334
	I-Mutant_PDB	0.253	0.869	0.756	0.135
	I-Mutant_SEQ	0.242	0.878	0.762	0.131
	AUTO-MUTE_RF	0.138	0.978	0.825	0.217
	AUTO-MUTE_SVM	0.057	0.965	0.800	0.049
	MUPRO_SVM	0.281	0.859	0.753	0.144
	PoPMuSiC2.0	0.344	0.931	0.824	0.328
	CUPSAT	0.390	0.740	0.676	0.112
Protein-protein interaction related
	iStable	0.357	0.943	0.831	0.379
	I-Mutant_PDB	0.207	0.858	0.733	0.088
	I-Mutant_SEQ	0.361	0.798	0.714	0.161
	AUTO-MUTE_RF	0.129	0.965	0.805	0.145
	AUTO-MUTE_SVM	0.079	0.970	0.799	0.100
	MUPRO_SVM	0.204	0.864	0.737	0.076
	PoPMuSiC2.0	0.100	0.964	0.798	0.091
	CUPSAT	0.461	0.778	0.717	0.216

ISSN: 1471-2105